PANX1 and head and neck squamous cell carcinoma: In this study we utilized the SCC‐13 cell line, publicly available cSCC and head and neck SCC (HNSCC) patient expression data, patient‐derived skin and cSCC tissues and a mouse model of cutaneous carcinogenesis to evaluate PANX1 and PANX3 expression in cSCC compared to normal skin and their role in cSCC malignancy.