Due to a lack of PANX3‐specific channel blockers and our previous findings that PANX3 deletion in isolated primary keratinocytes abrogates cell adhesion (O'Donnell et al., 2023), we utilized the DMBA/TPA mouse cutaneous carcinoma protocol (Filler et al., 2007; Halliwill et al., 2016; Sundberg et al., 1997) on a small subset of male WT and congenic global Panx3 KO mice (N = 5) to investigate the effects of PANX3 on papilloma and carcinoma formation and progression in vivo. The gene discussed is PANX3; the disease is papilloma.