In this study which contained a much larger N value of 502 HNSCC tumours and 44 adjacent normal tissues, PANX1 mRNA was found to be significantly increased in a subset of HNSCC (P = 6.54 × 10−14), with a FC of +2.20 compared to controls, similar to what was seen in cSCC. This evidence concerns the gene PANX1 and skin squamous cell carcinoma.