PANX3 and neoplasm: In the GSE191334 study, no significant differences were observed in PANX1 (P = 0.7165) or PANX3 (P = 0.952) mRNA expression between tissue types, whereas PANX1 transcript levels were significantly upregulated (P = 3.23 × 10−9) in cSCC tumours with a FC of +2.65 compared to controls in the GSE139505 study.