Our finding that PANX1 levels are increased in larger cSCC tumours also corresponds with our SCC‐13 PANX1 deletion and inhibition results and suggests that PANX1 channel‐dependent and PANX1 channel‐independent functions may influence cSCC cell proliferation, indicating a role for PANX1 in cSCC tumour progression. This evidence concerns the gene PANX1 and neoplasm.