Beginning with PANX3 we determined that in human full‐thickness skin samples, PANX3 was highly abundant (Fig. 8A), and PANX3 transcripts were significantly reduced (P = 0.0452) in cSCC tumour fragments compared to patient‐matched skin samples containing the epidermal and dermal layers (Fig. 8B). This evidence concerns the gene PANX3 and skin squamous cell carcinoma.