For PANX3, trends seen in cSCC corresponded to those observed in DMBA/TPA‐induced murine papillomas and carcinomas (Halliwill et al., 2016), previous immunofluorescence microscopy findings from our group (Cowan et al., 2012) and HNSCC in silico findings, where Panx3/PANX3 levels were reduced in each case compared to controls. This evidence concerns the gene PANX3 and head and neck squamous cell carcinoma.