Building on previous findings, three SNPs linked to verapamil response in migraine patients (Cutrer et al., 2021) and four functional SNPs of liver enzymes CYP3A4 were investigated for their association with verapamil treatment response in cluster headache patients; however, no significant association was found (Petersen et al., 2023). Here, CYP3A4 is linked to Cluster headache.