PLEKHA5 and Alzheimer disease: As displayed in Figure 3B, seven genes were identified causally associated with AD, including CCS (OR = 1.05, 95% CI = 1.01 – 1.09, method = IVW), CDS2 (OR = 0.94, 95% CI = 0.91 – 0.98, method = IVW), MYRIP (OR = 0.58, 95% CI = 0.39 – 0.85, method = Wald ratio), NRP1 (OR = 0.89, 95% CI = 0.84 – 0.94, method = IVW), PLEKHA5 (OR = 0.89, 95% CI = 0.83 – 0.96, method = IVW), POLR1D (OR = 1.08, 95% CI = 1.03 – 1.13, method = IVW), PPP4C (OR = 1.22, 95% CI = 1.12 – 1.33, method = IVW) (Supplementary Figure 1).