To determine the optimal concentration of IAAP in vitro and in vivo, the protein levels of IL-6 induced by LPS were measured after treatment with different concentrations of IAAP in HBE, THP-1, and BMDM (Figures S1B–S1D), and the anti-inflammatory effects of different concentrations of IAAP in LPS-induced ALI in mice were evaluated (Figures S1E–S1G). The gene discussed is IL6; the disease is acute respiratory distress syndrome.