IL33 and Granuloma: Furthermore, an independent group showed that individual ablation of TSLP, IL-25, or IL-33/ST2 had no impact on the progression of Schistosoma mansoni induced type 2 inflammation or fibrosis, whereas simultaneous disruption of all three mediators resulted in significant reductions in granuloma-associated eosinophils, fibrosis, and IL-13–producing ILC2 (Vannella et al., 2016).