In experimental cerebral malaria, infection triggered a dramatic increase of IL-33 expression in oligodendrocytes via ST2 pathway, and ST2-deficient mice were resistant to parasite induced neuropathology associated with attenuated neuroinflammation and exacerbated neurogenesis (Palomo et al., 2015; Reverchon et al., 2017). Here, IL33 is linked to cerebral malaria.