(2016) analyzed 3023 samples (2819 fever case samples and 204 control samples) and found that the positivity rates of interleukin-6 (IL-6) and IL-10 in children with bacteremia were 92.8% and 82.2%, respectively, which were higher than those of PCT (33.8%) and CRP (73.1%). Here, CALCA is linked to bacterial infectious disease with sepsis.