CD64 is a high-affinity immunoglobulin (Ig)-G Fc receptor (Fcγ RI) characterized by rapid and strongly induced expression on neutrophils in response to infection or the pro-inflammatory cytokines interferon (IFN)-γ and granulocyte colony-stimulating factor (G-CSF), and it is an early biomarker for the diagnosis of sepsis in patients, especially bacterial infection (Cid et al., 2010; Liu Q. et al., 2022). The gene discussed is CSF3; the disease is infection.