Late infantile neuronal ceroid lipofuscinoses (LINCL) is a devastating neurodegenerative disorder caused by mutations in the CLN2 gene, resulting in a deficiency of palmitoyl protein thioesterase-1 (PPT1) and subsequent accumulation of autofluorescent lipopigments. This evidence concerns the gene PPT1 and late infantile neuronal ceroid lipofuscinosis.