SQSTM1 and Alzheimer disease: The scaffolding protein p62/SQSTM1 is an autophagy receptor (151), WLJP-025p is a polysaccharide extracted from the traditional Chinese medicine Honeysuckle, and it has been shown that WLJP-025p can stimulate autophagy by up-regulating the expression of p62, and promote the ubiquitination and degradation of NLRP3, thereby improving AD (152).