MAP1LC3A and systemic sclerosis: Higher LC3 expression and increased autophagy were found in skin specimens from SSc patients compared to healthy controls (184), This finding is consistent with the findings of Tatsuhiko Mori et al., who found a significant increase in the number of positive points for LC3 in bleomycin-induced scleroderma skin of mice, suggesting that autophagy activation contributes to the pathogenesis of SSc (185).