SOCS3 and Alzheimer disease: Lack of macrophage autophagy leads to accumulation of the transcription factor CCAAT/enhancer binding protein beta (CEBPB), accumulation of CEBPB upregulates the expression of SOCS1 and SOCS3, and increased expression of SOCS1 and SOCS3 ameliorates AD by inhibiting M2 macrophage polarization (160).