Using scRNAseq on tumors treated with muAd-Ifnα vectors, we were able to demonstrate IFNα pathway activation in all cell clusters, and in the tumor cells antitumor properties were induced by activation of apoptotic pathways, while in the endothelial cell apoptosis, actin remodeling and inhibition of IL-1b and lL-1r2 contributed to anti-angiogenic effect. Here, IL1B is linked to neoplasm.