Gliadin peptide (Supplementary Table 1) restimulation of CD4 T cells derived from human donors with celiac disease induced a corresponding expansion of purified celiac donor CD8 Tregs when cultured with CD4 T cells (Figure 1C), consistent with data illustrating the expansion of CD8 Tregs in response to high-dose deamidated gluten (1). Here, CD4 is linked to celiac disease.