Mutations in the FGFR3 gene are associated with low PD-L1 expression in BC, high expression of MAN1B1 is related to poor prognosis, high expression of COL6A1 in tumor cells promotes tumor growth and metastasis, and high expression of NXPH4 is associated with poor prognosis in BC. The gene discussed is COL6A1; the disease is breast cancer.