Additionally, IP-10 has been suggested to increase the severity of virus infection and neuronal injury (24, 44), including neurotropic coronavirus (45), tick-borne encephalitis virus infection (46), Zika virus infection (47), and dengue virus infection (48), etc. Therefore, in this study, we first examined the expression of IP-10 in CV-A16-infected HUVECs. Here, CXCL10 is linked to viral infectious disease.