SYK and Sepsis: Based on this result and the role played by SYK in pro-inflammatory pathways involved in sepsis, we evaluated here, for the first time, the effects of a highly selective and potent SYK inhibitor (PRT062607 or P505-15) on both sepsis-induced cardiac dysfunction and MOF in a cecal ligation and puncture (CLP) murine model of sepsis (34–36).