NFKB1 and Sepsis: There is strong evidence that the NF-κB (nuclear factor-κB) pathway and the NLRP3 (NOD leucine-rich-repeat and pyrin domain–containing protein 3) inflammasome play a pivotal role in the pathophysiology of septic cardiomyopathy (and MOF), and the inhibition of both pathways contributes to the protective effects of a number of experimental interventions in murine sepsis (81–86).