To get a better understanding of the mechanism by which 15mg/kg PRT062607 reduces the cardiac dysfunction caused by CLP-sepsis, we investigated the effects of PRT062607 on the cardiac activation of SYK (the target), the phosphorylation of IKK and the expression of NLRP3 (two key elements of inflammatory pathways activated in sepsis) by western blot analysis. This evidence concerns the gene NLRP3 and Sepsis.