Given the key role played by the cardiac and circulatory (dys)function in the development of organ failure and, hence, in the outcome of septic patients, we focused our attention on the cardiac tissue of CLP-animals in order to address the mechanism of action of the beneficial effects of the SYK-inhibitor PRT062607 observed in murine sepsis (78–80). The gene discussed is SYK; the disease is Sepsis.