We employed machine learning algorithms to screen six genes, BATF, CXCR3, GIMAP5, GPR8, IGHM, and ISG20, that have been extensively investigated in other cancers, including lymphoma, melanoma, leukemia, breast cancer, multiple myeloma, hepatocellular carcinoma, and lung cancer. The gene discussed is ISG20; the disease is hepatocellular carcinoma.