In the meantime, rats with adult stress improved the performance of the leptin system by increasing the expression of the leptin receptor to some extent, but the rats with a history of maternal stress were unable to express more leptin receptors, especially in the face of adult stress, so they experienced more adverse effects as a result of leptin system dysfunction (one of its symptoms is the increase in anxiety-like behaviors, which can be seen in the results of this study). This evidence concerns the gene LEP and Anxiety.