found that the frequency of tumor-specific CD8+ T cells in the blood was positively correlated with ICI response and exhibited a senescent phenotype, while tumor-specific CD8+ T cells in the tumor showed an exhausted phenotype (73); and it was pointed out that the resistance to anti-PD-L1 originates from the decrease of HLA-I on tumor cells (73), which was consistent with the result of Paulson et al. The gene discussed is CD8A; the disease is neoplasm.