Through bioinformatics and MR analysis, we have predicted eight genes potentially relevant for the prevention and treatment of NSCLC, with five showing positive correlations (CA4, ZFP28, NCAPD2, FBN2, and PI16) and three exhibiting negative correlations (IL11RA, RFC5, and MLC1). The gene discussed is ZFP28; the disease is non-small cell lung carcinoma.