Tumour suppressor genes present in the thyroid include tissue inhibitor of metalloproteinase 3 (TIMP3), solute carrier family 5 member 8 (SLC5A8), Ras association domain family member 1, isoform A (RASSF1A), RAP1 GTPase activating protein (RAP1GAP), RAPβ2, phosphatase and tensin homolog (PTEN), and death associated protein kinase (DAPK). This evidence concerns the gene PTEN and neoplasm.