MYC and breast cancer: Atypical Hh activation can be observed downstream of oncogenic pathways, such as PI3K‐Akt‐mTOR [87], K‐Ras, c‐Myc, Wnt‐β‐catenin, and TGFβ [88], mediated through transcriptional upregulation of GLI1... Abnormal transcriptional upregulation of GLI1 can also be observed downstream of NF‐κB in claudin‐low breast cancer [89].