For example, overlapping gene associated with downregulated exon‐sense intergenic LncRNA Ankle1, associated with DNA endonuclease activity and DNA recombination, LncFancg with DNA damage response,40 and LncSrsf2 with the overlapping gene associated with protein kinase C activity,31 remain aberrantly expressed after hyperglycemia termination. The gene discussed is ANKLE1; the disease is Hyperglycemia.