Multivariate analysis identified the presence of CagA (p < 0.001) as an independent marker for predicting HPE responsiveness in gastric MALT lymphoma, and nuclear localization of NFATc1 (p = 0.053) showed a non-significant association with HPE responsiveness in gastric MALT lymphoma. This evidence concerns the gene S100A8 and gastric mucosa-associated lymphoid tissue lymphoma.