These findings suggest that the CagA-tyrosine phosphorylation-dependent signaling pathway contributes to the growth of HPE-responsive gastric MALT lymphoma and that CagA-stimulated NFATc1 signaling further restricts the progression of these tumors by activating the CDK inhibitors p21 and p27 (Fig. 3I) [48, 62]. The gene discussed is NFATC1; the disease is gastric mucosa-associated lymphoid tissue lymphoma.