When CagA and NFATc1 were used as single markers to predict HPE responsiveness in gastric MALT lymphoma, the positive predictive values (PPV) for CagA and NFATc1 were 87.0% and 84.3%, respectively, and the specificity values for CagA and NFATc1 were 78.1% and 75.0%, respectively (Table 4). This evidence concerns the gene S100A8 and holoprosencephaly.