In this study, we investigated whether CagA from HP translocates to B-lymphocytes cells, subsequently causing nuclear localization of p-CagA (tyrosine phosphorylation of CagA, CagAP−Tyr) and activation of CagA-signaling molecules (phosphorylation of SHP-2 and ERK as well as the expression of Bcl-xL) in lymphoma B-cells co-cultured with HP strains. The gene discussed is S100A8; the disease is lymphoma.