Our current findings indicate that the nuclear translocation of NFATc1 following CagA tyrosine phosphorylation after HP infection activates NFATc1-dependent genes such as p21 and p27 in both B-cell lymphoma cell lines (MA-1 and OCI-Ly3) [19, 43]. The gene discussed is S100A8; the disease is B-cell non-Hodgkin lymphoma.