In SLE, miR-182–96-183 upregulation induces a decrease in Foxo1/3a and/or microphthalmia-associated transcription factor (MITF), which plays a role in regulating T cell homeostasis and tolerance, resulting in T and B cell activation, autoantibody production, immune tolerance breakdown, and autoimmunity development [31]. Here, FOXO1 is linked to systemic lupus erythematosus.