AP1AR and bipolar disorder: Notably, we observed that the AP1AR-DTOE-induced mouse coding DEGs were significantly enriched in the PGC3 bipolar disorder GWAS genes [32] (29 + 79 overlapping genes; enrichment OR = 1.50 and P = 2.8e–4) and in the bipolar disorder-associated DEGs in the cerebral organoid RNA-seq dataset (29 + 531 overlapping genes; enrichment OR = 1.75 and P = 4.9e–24; Fig. 4A) [34].