In addition, Negr1-RE also improved anxiety-like behaviors, showing increased travel time in the central of the OFT chamber (Fig. 6 I)  but no difference in the total travel distance during the test session (30 min; Fig. 6J) and in times in the open arm of the EPM test (Fig. 6K), compared to the AP1AR-DTOE mice. The gene discussed is NEGR1; the disease is Anxiety.