TRANK1 and bipolar disorder: In addition, transcriptomic analysis of AP1AR-DTOE mouse mPFC revealed that 902 out of 2415 mouse DEGs displayed bipolar disorder-associated expression changes (P < 0.05) in the PsychENCODE brain RNA-seq dataset [25] or in the cerebral organoid RNA-seq dataset [34], including TRANK1, FURIN, GABRA2, and SYNE1, which are involved in modulating chemical synaptic transmission, trans-synaptic signaling, and synaptic signaling pathways.