To investigate the function of bipolar disorder-related upregulated AP1AR-DT, we generated a recombinant AAV (rAAV) carrying AP1AR-DT (for AP1AR-DT overexpression, AP1AR-DTOE) driven under the human neuron specific synapsin I promoter and used an empty AAV vector as a control. Here, SYN1 is linked to bipolar disorder.