We observed that out of the above 17 genes, only NEGR1 displays a significant reduction in the AP1AR-DTOE SK-N-SH cell lines (Log2FC = -5.82 and P = 0.026; Fig. 4A), consistent with the observations from AP1AR-DTOE mouse (Log2FC = -0.332 and P = 0.022) and the bipolar disorder cerebral organoid RNA-seq dataset (Log2FC = – 0.994 and P = 0.003). The gene discussed is AP1AR; the disease is bipolar disorder.