Importantly, some of the oncogene-encoded proteins enriched in DLBCL (LCK, LYN, HCK, VAV, OBF1) and GBM (KPCA, OLIG2) are also enriched in their tissue of origin (lymph node and brain, respectively) (Fig. 6B). The gene discussed is POU2AF1; the disease is glioblastoma.