Importantly, some of the oncogene-encoded proteins enriched in DLBCL (LCK, LYN, HCK, VAV, OBF1) and GBM (KPCA, OLIG2) are also enriched in their tissue of origin (lymph node and brain, respectively) (Fig. 6B). This evidence concerns the gene LYN and diffuse large B-cell lymphoma.