CD8A and neoplasm: As with TCR signalling, T cells activated in the milieu of uninfected or HK STm-treated tumours were able to produce high levels of IFN-γ (~50% IFN-γ+ CD8s at 48 h), but there was a dampening of cytokine expression in lymphocytes exposed to STm-harbouring tumours (p < 0.0001 live STm vs NT and HK STm at 48 h), particularly in CD8 T cells (Fig. 3E).