ASPG and neoplasm: Thus, we now hypothesised that the same mechanism suppressing T cell function (c-Myc depletion) was important for direct control of the tumour by Salmonella. To explore this, we first measured c-Myc levels in tumour organoids and found that c-Myc was indeed lowered by STmΔaroA, which could be reverted by the asparaginase-deficient STm mutant (Fig. 8A).