CDR2 and macular degeneration: Although our results do not provide final proof of a causal relationship between AT memory and the systemic yo-yo effect of accelerated weight gain, Hata et al. have shown that transplantation of WL epiAT into control mice enhances macular degeneration by impacting immune cells and angiogenesis and that epiAT macrophages retain an altered chromatin accessibility after WL28.