HTT and chronic obstructive pulmonary disease: SMR analysis revealed that MFSD10, TET2, and HTT did not exhibit significant causal effects on COPD in their corresponding tissues (PSMR−FDR > 0.05), nor did they share the same genetic signals with COPD in colocalization analysis (PP.H4 < 50%), suggesting that changes in their expression may not directly contribute to COPD pathogenesis (Supplementary Material 1, S6 and S7).