In the COPD discovery set, seven candidate genes primarily located on chromosomes 4 and 22 (MFSD10, GRK4, PPA2, TET2, XPNPEP3, HTT, and NOP14-AS1) were further analyzed using COJO analysis within each tissue to validate their associations with COPD and eliminate potential false positives due to LD. This evidence concerns the gene HTT and chronic obstructive pulmonary disease.