Moreover, positive, significant correlation of CHI3L2 expression with pSTAT-3 and pERK1/2 level was detected in tumor material and also regulation of ERK1/2 and STAT-3 phosphorylation in in vitro studies by CHI3L2 protein was observed, suggesting role of CHI3L2 in this signalling pathways activation in IDC. This evidence concerns the gene CHI3L2 and neoplasm.