CXCL10, also known as interferon-γ-inducible protein 10 (IP-10), has emerged as a noteworthy and promising biomarker for assessing the severity of renal diseases, including renal allograft dysfunction and LN.29,44,45 Previous studies have reported that CXCL10 expression can be induced in various cell types, such as mesangial cells, tubular epithelial cells, podocytes, and endothelial cells in a stimulus-specific manner.29 In our present study, the cellular origins of intrarenal CXCL10 and the regulatory mechanisms in LN were clarified thoroughly. The gene discussed is CXCL10; the disease is lobular neoplasia.