IFN-γ plays a key role in inducing CXCL10 production and promoting SLE disease progression.38 We used RNA sequencing (RNA-seq) analysis to compare the transcriptomes of interferon-responsive (IFN-γ high) SLE, interferon-non-responsive (IFN-γ low), and healthy control (HC) human PBMC samples from the GEO database. Here, IFNG is linked to systemic lupus erythematosus.