To demonstrate the functions of EphrinB2 through the CDK5/ISL1/VEGFR3 signaling pathway in enhancing lymphangiogenesis and exerting cardioprotective effects after acute myocardial infarction (MI), the VEGFR3 inhibitor MAZ51 was applied in vivo (supplementary Fig 13a). Here, CDK5 is linked to myocardial infarction.