While EIF4E overexpression was reported to induce autism spectrum disorders (ASD) like behavior deficits, depression-like behavior and cognitive impairment (Christos G. Gkogkas et al., 2012; Thu N. Huynh et al., 2015; Argel Aguilar-Valles et al., 2018)., the mechanisms are not fully explored. The gene discussed is EIF4E; the disease is Cognitive impairment.