It has been reported that decreased oxytocin expression due to mutations in autism susceptibility genes Cntnap2 and Shank3b has been observed to microglial activation (M. Yang et al., 2023; Yuan et al., 2016) Overexpression of eIF4E can result in abnormal protein synthesis and promote neu-neuroinflammation through microglial activation. Here, CNTNAP2 is linked to autism.