PSMA6 and Cognitive impairment: Current evidence indicates that 5-hydroxytryptamine 7 (5-HT7) receptor antagonism may contribute to positive effects on mood and memory.28 29 On the other hand, histamine-1, alpha-1 and alpha-2A receptor antagonism may lead to depressant effects on the central nervous system, which could cause potential cognitive impairment.30 31 Lurasidone is a strong 5-HT7 receptor antagonist, but it also has weak antagonism effects on the histamine-1, alpha-1 and alpha-2A receptors.30