Meanwhile, free mtDNA can stabilize the oligomers of VDAC1 by binding to the N‐terminal domain of VDAC1.[25] The VDAC1 inhibitor VBIT‐4 has been demonstrated to alleviate the inflammatory process of DSS‐induced colitis in mice by downregulating the oligomerization level of VDAC1.[26] However, it is unclear whether oligomeric inhibitors of VDAC1 are effective drugs for treating ALI. This evidence concerns the gene VDAC1 and colitis.