A case of early-onset Alzheimer’s disease was identified in an individual who was a compound heterozygote, carrying both the African-origin Thr96Lys/Trp191*/Leu211Pro haplotype and the Native American c.469C>T (p.His157Tyr) variant in the TREM2 gene [45]. The gene discussed is TREM2; the disease is Alzheimer disease.