In contrast to the presumed OCA founder effect mutations seen for the TYR and OCA2 genes, one of the Altiplano Cundiboyacense family members shown in Fig 3, and two of the eight unrelated OCA patients from Altiplano Cundiboyacense, also show evidence for compound heterozygous mutations with distinct ancestral origins. This evidence concerns the gene TYR and oculocutaneous albinism.