By integrating DNA methylation and gene expression data from the 33 different cancer types in TCGA, we identified a cell cycle-related community of emQTL characterized by the loss of enhancer methylation situated in transcription factor binding regions for FOSL1/2 and JUN (parts of the AP-1 complex) with concomitant upregulation of proliferation-related genes. The gene discussed is FOS; the disease is cancer.