The top five hub genes for the hormone-like community were KRT18, JUP, KRT8, SH2D3A and PDLIM1 (S1B Table); KRT18 and KRT8 are luminal markers in breast cancer while JUP (plakoglobin), SH2D3A and PDLIM1 are relatively undescribed in the context of cancer. This evidence concerns the gene JUP and cancer.