The top five hub genes for the hormone-like community were KRT18, JUP, KRT8, SH2D3A and PDLIM1 (S1B Table); KRT18 and KRT8 are luminal markers in breast cancer while JUP (plakoglobin), SH2D3A and PDLIM1 are relatively undescribed in the context of cancer. The gene discussed is SH2D3A; the disease is cancer.