Moreover, DNA methylation at cg23320499 was negatively correlated with the expression of CREBL2 in several cancer types such as thymoma (p-value = 8.71e-11, r-value = -0.6) and bile duct cancer (Fig 5B; p-value = 1.54e-02, r-value = -0.5). Here, CREBL2 is linked to cancer.