For example, patients with AJCC cancer Stage 4, the use of EGFR inhibitor, age above the mean of diagnosis (aged above 65), T‐staging 4, lymphovascular invasion, all these five factors will be given one point so that each patient would have a score out of five, five being the most at risk for bone metastasis, while patients with a score of zero would be at least risk. Here, EGFR is linked to cancer.