Of note is that the phenotype reported in the consanguineous family is that of Wolfram Syndrome (diabetes insipidus and diabetes mellitus with optical atrophy, and deafness, DIDMOAD) (Pallotta et al., 2019), which is quite distinct from the phenotype of CDK13‐related disorder described so far. Here, CDK13 is linked to Leber hereditary optic neuropathy.