ERBB2 and breast carcinoma: Breast cancer is the most common malignancy among women, with the highest incidence andmortality rates among all types of female cancers.[1, 2] Human epidermal growth factor receptor 2 (HER2) is a transmembrane glycoprotein that, through dimerization, activates downstream signaling pathways, promoting the proliferation and survival of malignant phenotypes.