The infiltration levels of both CD8+T cells and macrophages in the pathological process of LGG are negatively correlated with the clinical prognosis of patients with glioma.46,47 More importantly, the expression of DSN1 negatively correlated with IDH mutations, and the infiltration level of immune cells in the IDH mutation group was substantially lower than that in the wild-type group. The gene discussed is CD8A; the disease is central nervous system cancer.