Previous studies have shown that DSN1 is related to the cell cycle and is involved in osteosarcoma cells.22 In addition, it has been established that cell cycle pathway-related genes promote the proliferation of liver and gastric cancer.58,59 Therefore, we speculate that DSN1 may promote the malignant proliferation of LGG cells by regulating the cell cycle pathway, and abnormally high expression of DSN1 leads to an unsatisfactory prognosis for patients with glioma. This evidence concerns the gene DSN1 and osteosarcoma.