CDK4/6, an essential molecule for the cell cycle, has been reported to stabilize the expression of Cullin 3-SPOP E3 ligase by regulating the phosphorylation of speckle-type POZ protein (SPOP), which mediates the proteasomal degradation of PDL1.17 Thus, targeting cell cycle-related factors could further explore the mechanisms of tumor immunity. The gene discussed is CD274; the disease is neoplasm.