Villa's research demonstrated that ARIH1 regulates mitophagy in cancer cells in a PINK1‐dependent manner,[38] while Zhou's study found that the PINK1‐SIAH1 axis‐mediated mitophagy influences the sensitivity of hepatocellular carcinoma to sofilanib.[39] However, the role of these related pathways in MSCs osteogenic differentiation has not yet been reported. This evidence concerns the gene SIAH1 and cancer.