Consistently, previous studies also indicated an important role of WAC in cell differentiation.[36, 37] Li’ study demonstrated an essential role of WAC‐mediated uH2B in plasma cell differentiation,[36] and Karpiuk and his colleagues revealed that WAC coordinated H2Bub1 during MSC differentiation.[37] While differently, our study is the first to systematically investigate the expression and mechanism of WAC in MSC osteogenesis and evaluate its application value on osteoporosis and bone repair. Here, WAC is linked to osteoporosis.