Notably, WAC deletion has been associated with DeSanto‐Shinawi syndrome, a rare autosomal dominant disorder that manifests as mental retardation and learning disabilities.[34] Furthermore, studies had linked mutations and deletions in the WAC gene to conditions such as growth retardation, unique cranial developmental abnormalities, as well as neurological disorders like autism and attention deficit disorder.[35] However, few studies have investigated the role of WAC on bone metabolism. Here, WAC is linked to DeSanto-Shinawi syndrome.