LYZL4 and Alzheimer disease: APPSAA is a new knock‐in mouse model that exhibits earlier disease‐relevant biology and the progressive accumulation of parenchymal amyloid plaques and vascular amyloid deposits of AD.[27] In the APPSAAKI/KI mouse model, Lyzl4 expression was markedly elevated at 8 months of age compared to WT controls (Figure S1A, Supporting Information).