LYZL4 and Alzheimer disease: Aβ, a particularly neurotoxic protein aggregate that accumulates in the AD brain, has been considered a major inducer of neuroinflammation in AD and a cause of central nervous system disruption.[31] To explore the potential relationship between Lyzl4 and Aβ in AD, we isolated and cultured both primary microglia and BV2 cells in vitro, then stimulated the cells with oligomeric Aβ1‐42 at concentrations of 1, 2, and 4 μm.