To identify key genes potentially involved in Alzheimer's disease (AD), we first collected primary microglia from APP/PS1 (AD) mice and wild‐type (WT) mice at various ages (2, 4, 6, 9, and 12 months) and performed RNA sequencing, as described in previous studies.[25] Using Weighted Gene Co‐Expression Network Analysis (WGCNA),[26] we constructed a gene co‐expression network to identify modules of highly correlated genes. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.