Lastly, antigangliosides-ab screening is also indicated in CANOMAD/CANDA suspicion, i.e., in case of chronic ataxic sensory neuropathy with IgM monoclonal gammopathy, as the differential diagnosis of chronic sensory ataxic neuropathies are broad, including toxic, metabolic, mitochondrial or vitamin deficiencies (95). The gene discussed is CD40LG; the disease is monoclonal gammopathy.