GSK3B and hepatocellular carcinoma: The relationship between exercise and angiogenesis is also supported in mice bearing hepatocellular carcinoma where the swimming intervention impaired hypoxia through the inhibition of HIF-1α and serine/threonine kinase 1 (AKT)/Glycogen synthase kinase 3 beta (GSK-3β)/β-CATENIN signaling pathways (51).