Aerobic exercise induces the activation of p53-tumor suppression protein expression in LC mouse models; similarly, exercise increases the expression of BAX and BAK and CASPASE-3 proteins, and as suggested in other types of cancer, exercise could influence the expression of BECLIN-1, a bridge protein, linked to autophagy pathways and other proteins associated to the cachexia. Here, BAK1 is linked to neoplasm.