Some studies have explored the use of probiotics to potentially reduce the risk of GDM by improving glucose metabolism and insulin sensitivity in pregnant women.17 In a more recent Cochrane review, high certainty evidence suggests an increased risk of hypertensive disorders of pregnancy (pre-eclampsia) with probiotic use18, therefore, caution is warranted in recommending probiotics in pregnancy at this stage. The gene discussed is INS; the disease is gestational diabetes.