Tang San, et al. (Tang et al., 2023) found that HTTLT significantly reduced the NIHSS score after cerebral ischemia/reperfusion, increased the expression of brain-derived neurotrophic factor (BDNF), and reduced the levels of neuron-specific enolase (NSE), high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) levels in rats. This evidence concerns the gene ENO2 and Cerebral ischemia.