NFKB1 and brain ischemia: On the other hand, found that kaempferol in the decoction not only modulated the classical pro-inflammatory NF-kB signaling pathway to promote the expression of anti-apoptotic proteins, inhibited neuronal death induced by cerebral ischemia and glial cell activation, reduced the activation and number of neutrophils in peripheral blood and brains of the rats, and significantly suppressed the levels of oxidative stress, inflammation, and apoptosis, which in turn alleviated IS .