Mutations in the PIK3CA gene can lead to sustained activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway (Chen et al., 2018), promoting the proliferation, survival, migration, invasion, angiogenesis, and drug resistance of tumor cells (Stefani et al., 2021). The gene discussed is AKT1; the disease is neoplasm.