Researchers have discovered many genes related to the occurrence and development of colorectal cancer through genomic studies, including but not limited to the PIK3CA (Chang et al., 2018), KRAS (Prior et al., 2020), APC (Cen et al., 2021), SMAD4 (Zhao et al., 2018), and BRAF genes (Lan et al., 2021), among which the PIK3CA gene has attracted widespread attention. Here, PIK3CA is linked to colorectal cancer.