Colorectal cancer with PIK3CA mutations often accompanies mutations in genes such as KRAS, BRAF, PTEN, AKT1, all of which are components of the PI3K signaling pathway or MAPK signaling pathway (Wang and Pan, 2022; Mirzapoor Abbasabadi et al., 2023). The gene discussed is AKT1; the disease is colorectal cancer.