Colorectal cancers with mutations in the PIK3CA gene also tend to be accompanied by mutations in other oncogenes, such as KRAS, BRAF and TP53, as well as higher tumor mutational load (TMB), which may lead to a more malignant and complex biological behavior of the tumor (Zhuang et al., 2021; Wang and Pan, 2022). Here, PIK3CA is linked to colorectal cancer.