JSO treatment not only alleviates inflammation, but also significantly improves markers of neuroplasticity, such as BDNF, PSD-95, and SYP, suggesting that its antidepressant effects are partly due to enhancing synaptic connectivity and neuronal survival, a process that could counteract the neuronal damage induced by chronic stress. This evidence concerns the gene DLG4 and Joubert syndrome with ocular defect.