CRS markedly increased the protein expression levels of NLRP3, Asc, Caspase-1, Sting, and c-GAS in the Hip (F(5,29) = 7.533, p < 0.05; F(5,14) = 3.301, p < 0.05; F(5,21) = 11.520, p < 0.05; F(5,12) = 2.855, p < 0.05; F(5,22) = 6.399, p < 0.05) and in the mPFC (F(5,25) = 5.418, p < 0.001; F(5,12) = 7.496, p < 0.01; F(5,12) = 4.109, p < 0.01; F(5,13) = 9.997, p < 0.05; F(5,12) = 9.049, p < 0.01) regions (Figure 4). Here, CASP1 is linked to congenital rubella syndrome.