CRS increased the protein expression levels of Iba-1 and GFAP in the Hip (F(5,18) = 17.506, p < 0.001; F(5,29) = 2.865, p < 0.05) and mPFC (F(5,18) = 2.853, p < 0.05; F(5,29) = 16.046, p < 0.01); JSO (50, 100, and 200 mg/kg) significantly decreased the Iba-1 protein expression level in the Hip (p < 0.001, p < 0.01, p < 0.001, respectively), and GFAP expression level in the mPFC (p < 0.001, p < 0.05, p < 0.01, respectively). The gene discussed is AIF1; the disease is Joubert syndrome with ocular defect.