In CRS mice, the protein expression levels of BDNF, PSD-95, and SYP were significantly reduced in the Hip (F(5,22) = 6.264, p < 0.01; F(5,36) = 7.118, p < 0.001; F(5,14) = 7.001, p < 0.001) and mPFC (F(5,18) = 3.029, p < 0.05; F(5,26) = 5.202, p < 0.05; F(5,27) = 5.434, p < 0.05). Here, BDNF is linked to congenital rubella syndrome.