While citalopram primarily enhances serotonin availability, JSO appears to influence both neuroinflammation and neuroplasticity, as indicated by its effects on BDNF and synaptic proteins, such as PSD-95 and SYP, which are crucial for synaptic health and resilience in stress-related disorders (Gao et al., 2018). This evidence concerns the gene DLG4 and stress-related disorder.