In the high-CLDN18.2 expression group of CRC, TP53 was not among the top-ranked mutated genes, and the APC gene mutation rate in the low-CLDN18.2 expression group was much higher than that in the high-CLDN18.2 expression group (Supplementary Figures S2A, B). This evidence concerns the gene TP53 and colorectal carcinoma.