Periodontitis patients have significantly elevated levels of LY96, which leads to the formation of LY96-TLR4-CD14 complexes that trigger the myeloid differentiation factor-88 (MyD88) pathway, resulting in TNF-α, IL-6, IL-8, and IL-2 production in the gingival tissue (53). Here, CXCL8 is linked to periodontitis.