Additionally, lncRNA HOXA11-AS/lncRNA NR2F1-AS1 may regulate cyclin-dependent kinase 6 (CDK6) expression by targeting miR-454-3p, which may have oncogenic roles in PC and is strongly associated with multiple immune cells and cellular infiltration and three immune checkpoints (PD-L1, PD-L2 and HAVCR2) (60), suggesting that lncRNA HOXA11-AS/lncRNA NR2F1-AS1 may regulate immune checkpoints through the miR-454-3p- CDK6 axis, thereby mediating immune escape. This evidence concerns the gene CD274 and pachyonychia congenita.