CD274 and pachyonychia congenita: On the contrary, miR-194-5p enhances the toxic effect of CD8 T cells on PC cells by targeting PD-L1, thereby inhibiting the proliferation, migration and invasion of PC cells, but its specific mechanism of action remains to be investigated (55).In addition, lncRNAs can act as miRNA “molecular sponge” to target PD-L1 expression.