For example, miR-363-3p can inhibit PANC-1 proliferation by regulating squalene epoxidase (SQLE) expression in PAAD, where SQLE regulates tumor immune cell infiltration, immune checkpoints, and the TME, and high SQLE expression predicts depletion of cytotoxic lymphocytes and loss of antitumor capacity (58). Here, SQLE is linked to neoplasm.