HK2 and pachyonychia congenita: In addition, lncRNA SH3BP5-AS1, which is up-regulated in GEM-resistant PC cells, activates the expression of CTBP1 in Wnt pathway through competitive binding of ceRNA to miR-139-5p, which promotes GEM-resistant PC cells and tumor invasiveness (72).Moreover, Glycolysis-related LINC 02432 up-regulated in PAAD predicts the activity of PAAD patients against EGFR、MEK and ERK inhibitors by regulating hsa-miR-98-5 p/hexokinase 2 (HK2) axis (73).